Zhou Lab

group shot of Zhou lab

Zhou Lab Research Statement

The goal of the Zhou laboratory is to determine the transcriptional regulation of mucosal immune responses and host-microbiome interactions. We have characterized the interactions between various transcription factors (e.g., RORγt and Foxp3) involved in specifying the development of Th17 cells and the related iTreg lineage as well as how these interactions eventually determine whether the T cell adopts the Th17 or Treg cell fate. Recently, we have been focusing on the molecular regulation of innate lymphoid cells (especially RORγt+ innate lymphoid cells) by the aryl hydrocarbon receptor (Ahr). Ahr is a ligand-dependent transcription factor under steady-state physiological conditions, during inflammation or autoimmunity. Our work has implications for understanding how to modulate mucosal immune responses in different disease settings, and it may ultimately lead to the identification of new therapeutic targets for human diseases such as IBD or colon cancer.

The Zhou lab was established in October, 2009 at Northwestern University, Chicago. The lab moved to UF, Gainesville in December, 2015.


Lab Personnel 

Dr. Zhou turning a page, sitting in front of a microscope

Liang Zhou, MD, PhD

Professor

Principal Investigator

 

Kristin Oliff using a pipette

Kristen Oliff

Laboratory Manager

Li using pipette

Shiyang Li

Research Assistant Professor

Zheng Fu uses lab equipment

Zheng Fu

Postdoctoral Fellow

Lifeng Xiong uses a pipette

Lifeng Xiong

Postdoctoral Fellow

Jian Ye uses a pipette

Jian Ye

Postdoctoral Fellow

John Bostick uses an agitator

John Bostick

PhD Student

Joseph Dean using a pipette
Joseph Dean

PhD Student

 


Lab Alumni

 

Zhou lab group shot 2016

Postdoctoral Fellows:

Ju Qiu (2009 – 2014)
Olga Malykhina (2011)
Lei He (2011 – 2014)
Jianlei Hao (2012 – 2013)
Aki Ueda (2012 – 2014)
Yetao Wang (2013 – 2015)

Graduate Students:

Jennifer Heller (2010 – 2014)
Aki Ueda (2010 – 2012)

Undergraduate Students:

Kyoo Seok Shim (UIC) (2010)
Ari Lederman (2011 – 2012)
Aileen Lee (2011 – 2014)
Jacob Weiderman (UF) (2016 – 2018)

Technicians/Lab Managers:

Priscilla Shamulailatpam (2014 – 2015)
Hui Li (2015 – 2018)